BDBM174015 US9688661, 4-(6-Aminopyrimidin-4-yl)-1-(5-chloro-2-ethylphenyl)-1H-pyrrole-2-carboxamide (compd 235)

SMILES CCc1ccc(Cl)cc1-c1cn(cc1C(N)=O)-c1cc(N)ncn1

InChI Key InChIKey=PJQOCKSDYYBJLI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 174015   

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174015(US9688661, 4-(6-Aminopyrimidin-4-yl)-1-(5-chloro-2...)
Affinity DataIC50: 79nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174015(US9688661, 4-(6-Aminopyrimidin-4-yl)-1-(5-chloro-2...)
Affinity DataIC50: 8nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174015(US9688661, 4-(6-Aminopyrimidin-4-yl)-1-(5-chloro-2...)
Affinity DataIC50: 32nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In DepthDetails
US Patent