BDBM173968 BDBM50069310::US9688661, 3-(5-Chloro-2-methylphenyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-2-carboxamide (compd 123)

SMILES Cc1ccc(Cl)cc1-c1cc([nH]c1C(N)=O)-c1ncnc2[nH]ccc12

InChI Key InChIKey=HAKZDKNTSAPKJO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 173968   

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM173968(BDBM50069310 | US9688661, 3-(5-Chloro-2-methylphen...)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM173968(BDBM50069310 | US9688661, 3-(5-Chloro-2-methylphen...)
Affinity DataIC50: 33nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM173968(BDBM50069310 | US9688661, 3-(5-Chloro-2-methylphen...)
Affinity DataIC50: 5nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM173968(BDBM50069310 | US9688661, 3-(5-Chloro-2-methylphen...)
Affinity DataIC50: 23nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
Go to US Patent