BDBM173937 US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-2-carbonitrile (compd 72)

SMILES Cc1ccc(Cl)cc1-c1cn(cc1C#N)-c1cc(N)ncn1

InChI Key InChIKey=PSZMTRRKARIKBT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 173937   

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM173937(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 17nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM173937(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 7nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM173937(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50: 38nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
Go to US Patent