BDBM168619 US9079852, Table F, Compound 4

SMILES NC(=O)Nc1ccc(OC[C@@H](O)CN2CCN(CC2)c2ccc(Cl)cc2)cc1

InChI Key InChIKey=GSOWCEUNQPJIFR-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 168619   

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Emory University

US Patent
LigandPNGBDBM168619(US9079852, Table F, Compound 4)
Affinity DataIC50: 340nMAssay Description:Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Emory University

US Patent
LigandPNGBDBM168619(US9079852, Table F, Compound 4)
Affinity DataIC50: 46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Emory University

US Patent
LigandPNGBDBM168619(US9079852, Table F, Compound 4)
Affinity DataIC50: 452nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emory University

US Patent
LigandPNGBDBM168619(US9079852, Table F, Compound 4)
Affinity DataKi:  1.30E+4nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
Go to US Patent