BDBM1683 (4S,5R,6S,7S)-1,3,4,7-tetrabenzyl-5,6-dihydroxy-1,3-diazepan-2-one::Cyclic Urea diastereomer 25

SMILES O[C@H]1[C@@H](O)[C@H](Cc2ccccc2)N(Cc2ccccc2)C(=O)N(Cc2ccccc2)[C@H]1Cc1ccccc1

InChI Key InChIKey=HZUCRWWOEVMAPC-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1683   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1683((4S,5R,6S,7S)-1,3,4,7-tetrabenzyl-5,6-dihydroxy-1,...)
Affinity DataKi:  1.71E+3nM ΔG°:  -8.18kcal/molepH: 5.5 T: 2°CAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2004
Entry Details Article
PubMed