BDBM168191 US9688642, 2

SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)C

InChI Key InChIKey=FNXMDDKBLZLDDD-UHFFFAOYSA-N

Data  6 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 168191   

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168191(US9688642, 2)
Affinity DataEC50:  2nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2018
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168191(US9688642, 2)
Affinity DataEC50:  8nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2018
Entry Details
Go to US Patent

TargetCytochrome P450 2C8(Human)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of recombinant CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataEC50:  38nMAssay Description:Agonist activity at mouse GPR40 assessed as increase in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataEC50:  8.62E+5nMAssay Description:Agonist activity at GPR40 receptor in rat INS1(832/13) cells assessed as induction of IP1 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataEC50:  547nMAssay Description:Agonist activity at rat GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168191(US9688642, 2)
Affinity DataEC50:  894nMAssay Description:Agonist activity at human GPR40 receptor expressed in CHOK1 cells assessed as induction of IP1 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168191(US9688642, 2)
Affinity DataEC50:  17nMAssay Description:Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168191(US9688642, 2)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed