BDBM167699 US9073922, 186::US9796708, Example 186

SMILES COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1

InChI Key InChIKey=NDLAFOKSJSLKGG-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 167699   

TargetCyclin-dependent kinase 8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of CDK8 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of CDK8 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 7(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CDK7 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 6(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 298nMAssay Description:Inhibition of CDK6 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 16nMAssay Description:Inhibition of CDK4 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of CDK2 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 3.04E+3nMAssay Description:Inhibition of CDK1 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CDK9 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 28nMAssay Description:Inhibition of CDK9 in human A-431 cells assessed as reduction in RNA polymerase2 phosphorylation at ser2 residue incubated for 4 hrs by In-cell Weste...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 4nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 7(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of CDK7 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of CDK2 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of CDK1 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 298nMAssay Description:Inhibition of CDK6 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 155nMAssay Description:Inhibition of CDK4 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167699(US9073922, 186 | US9796708, Example 186)
Affinity DataIC50: 4nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In DepthDetails
US Patent