BDBM166614 3-(1-(3-(1H-Imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(furo[2,3-b]pyridin-3-yl)-1H-pyrrole-2,5-dione (5n)

SMILES O=C1NC(=O)C(=C1c1coc2ncccc12)c1cn(CCCn2ccnc2)c2ccccc12

InChI Key InChIKey=MHIHFTFFTDQVFQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 166614   

TargetGlycogen synthase kinase-3 beta(Human)
Zhejiang University of Technology

LigandPNGBDBM166614(3-(1-(3-(1H-Imidazol-1-yl)propyl)-1H-indol-3-yl)-4...)
Affinity DataIC50: 210nMAssay Description:The test methods for GSK-3β, PKCE, JAK2, BRAF, IKK2 and Drak2 inhibitory activities were reported in Molecules; 18:5498-5516. The PKA kinase ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM166614(3-(1-(3-(1H-Imidazol-1-yl)propyl)-1H-indol-3-yl)-4...)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-fused IDH1 R132H mutant expressed in Escherichia coli using alpha-ketoglutarate as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed