BDBM164883 US9067888, 33
SMILES COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1
InChI Key InChIKey=QNWXRLPZIFMTBK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 164883
TargetCyclin-A1/Cyclin-dependent kinase 2(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human His/GST-tagged CDK2/Cyclin A expressed in baculovirus infected Sf9 cells using Histone H1 as substrate after 80 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.46E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of human CDK9 in human MV4-11 cells assessed as decrease in RNAP2 phosphorylation at Ser2 by western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 220nMAssay Description:Inhibition of CDK9 in human MV4-11 cells assessed as induction of caspase-3/7 activation measured after 6 hrs followed by Caspase-glo reagent based a...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of CDK9 in human MCF7 cells assessed as reduction in RNA Polymerase 2 CTD phosphorylation at Ser2 residues measured after 6 hrs by immunof...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human CDK3/cyclin E expressed in baculovirus infected Sf9 insect cells after 80 mins in presence of [33P]ATP by microbeta s...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human CDK1/cyclin B expressed in baculovirus infected Sf9 insect cells after 80 mins in presence of [33P]ATP by microbeta s...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human His/GST-tagged CDK5/p35 expressed in baculovirus infected Sf9 insect cells using Rb-CTF as substrate after 80 mins in...More data for this Ligand-Target Pair
Affinity DataIC50: 94nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using cdk7tide peptide as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair
Affinity DataIC50: 903nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair
Affinity DataIC50: 219nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair
Affinity DataIC50: 168nMpH: 7.5Assay Description:In vitro kinase assay analysis may be performed using standard techniques described in the art. These techniques are also used by commercial services...More data for this Ligand-Target Pair