BDBM164062 US9062078, 192::US9062078, 279::US9475819, 192::US9637496, 279::US9695183, 279

SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1

InChI Key InChIKey=BDCUQVJRZGYIDS-UHFFFAOYSA-N

Data  21 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 164062   

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  8nM ΔG°:  -10.3kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  8nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  8nM ΔG°:  -10.3kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  15nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  15nM ΔG°:  -11.2kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  15nM ΔG°:  -9.91kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  52nM ΔG°:  -9.23kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  52nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  52nM ΔG°:  -9.23kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  52nM ΔG°:  -9.23kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  60nM ΔG°:  -9.15kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  60nM ΔG°:  -9.15kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  60nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  60nM ΔG°:  -10.3kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  1.10E+3nM ΔG°:  -8.53kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  1.10E+3nM ΔG°:  -8.53kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  1.10E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  1.50E+3nM ΔG°:  -8.34kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  1.50E+3nM ΔG°:  -8.34kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  1.50E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164062(US9475819, 192 | US9062078, 192 | US9695183, 279 |...)
Affinity DataKi:  1.50E+3nM ΔG°:  -8.34kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In DepthDetails
US Patent