BDBM162879 US11419874, Example 28::US9056863, Example Ic1

SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl

InChI Key InChIKey=SNQXTEAQGLZIDL-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 162879   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 69nMpH: 7.6 T: 2°CAssay Description:A typical PDE2A assay was performed as follows: the assay was performed in 60 μL samples containing a fixed amount of the PDE2A enzyme (sufficie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
Go to US Patent

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 6.92E+3nMAssay Description:Inhibition of full length human PDE11A4 expressed in HEK cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 480nMAssay Description:Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE9A1 expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE7A1 expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 5.89E+3nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE4D3 expressed in Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE3B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE1A by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 29nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 29nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

LigandPNGBDBM162879(US9056863, Example Ic1 | US11419874, Example 28)
Affinity DataIC50: 480nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent