BDBM16274 2-({2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile::CHEMBL425483::quinazolinone-based inhibitor 1c

SMILES N[C@@H]1CCCN(C1)c1nc2ccc(F)cc2c(=O)n1Cc1ccccc1C#N

InChI Key InChIKey=XMOSOHDOZCRMML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16274   

TargetDipeptidyl peptidase 4(Human)
Takeda Pharmaceutical

LigandPNGBDBM16274(CHEMBL425483 | 2-({2-[(3R)-3-aminopiperidin-1-yl]-...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Takeda Pharmaceutical

LigandPNGBDBM16274(CHEMBL425483 | 2-({2-[(3R)-3-aminopiperidin-1-yl]-...)
Affinity DataIC50: 1.00E+5nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2007
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM16274(CHEMBL425483 | 2-({2-[(3R)-3-aminopiperidin-1-yl]-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed