BDBM16223 1H-pyrrolo[2,3-b]pyridine::7-azaindole::compound 2

SMILES c1cc2cccnc2[nH]1

InChI Key InChIKey=MVXVYAKCVDQRLW-UHFFFAOYSA-N

Data  7 IC50  1 Kd

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 16223   

LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 1.00E+5nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
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PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of AKT1 expressed in Escherichia coli or baculovirus-infected insect cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of JNK1 expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of IKK-beta expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of recombinant His-tagged MTH1 (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP as substrate incubated for 15 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataKd:  9.60E+4nMAssay Description:Binding affinity to recombinant His-tagged MTH1 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by isother...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 3.91E+5nMAssay Description:Inhibition of Axl (unknown origin) using 5'FAM labeled KKKKEEIYFFF-NH2 peptide as substrate incubated for 1.5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed