BDBM161392 US10124003, Ex. Compound 5::US10835536, Ex. Comp 5::US10894048, Ex Comp 5::US9108973, 5

SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12

InChI Key InChIKey=SENVOZNIDWYYED-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 161392   

TargetFibroblast growth factor receptor 1(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 1.40nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2016
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2016
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 0.200nMAssay Description:Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2016
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 0.5nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2016
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 1.40nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 0.200nMAssay Description:The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent