BDBM16096 2-[(6-bromonaphthalene-2-)amido]benzoic acid::2-{[(6-bromonaphthalen-2-yl)carbonyl]amino}benzoic acid::Inhibitor 4

SMILES OC(=O)c1ccccc1NC(=O)c1ccc2cc(Br)ccc2c1

InChI Key InChIKey=KNVPXLPBRSRJCV-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16096   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))TBA
LigandPNGBDBM16096(2-{[(6-bromonaphthalen-2-yl)carbonyl]amino}benzoic...)
Affinity DataIC50: 1.41E+5nMAssay Description:Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM16096(2-{[(6-bromonaphthalen-2-yl)carbonyl]amino}benzoic...)
Affinity DataKi:  1.10E+3nM ΔG°:  -8.12kcal/mole IC50: 8.40E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))TBA
LigandPNGBDBM16096(2-{[(6-bromonaphthalen-2-yl)carbonyl]amino}benzoic...)
Affinity DataKi:  1.64E+4nM ΔG°:  -6.52kcal/mole IC50: 1.43E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2007
Entry Details Article
PubMed