BDBM160576 US9045389, 8

SMILES OC(=O)CCNC(=O)c1ccc(cc1)-c1cc(Cl)ccc1CNc1ccc(cc1)-c1ccc(Cl)cc1Cl

InChI Key InChIKey=UOXBWPOEKZEVKV-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 160576   

TargetGlucagon receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM160576(US9045389, 8)
Affinity DataIC50: 67nMAssay Description:Antagonist activity at human glucagon receptor expressed in HEK293 cell membranes assessed as inhibition of glucagon-stimulated intracellular cAMP fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetPro-glucagon(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160576(US9045389, 8)
Affinity DataKi:  33nM ΔG°:  -9.48kcal/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
Go to US Patent

TargetGlucagon receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM160576(US9045389, 8)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]-glucagon from full length human glucagon receptor expressed in HEK293 cell membranes after 2 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed