BDBM160520 US10280160, Example 12.::US9682969, 12

SMILES COc1ccc2c(nn(CC(=O)N(C3CC3)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(F)c1

InChI Key InChIKey=QJUANSRCVITYNW-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 160520   

LigandPNGBDBM160520(US9682969, 12 | US10280160, Example 12.)
Affinity DataEC50: <1.00E+4nMAssay Description:This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
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TargetCystic fibrosis transmembrane conductance regulator(Human)
Flatley Discovery Lab

US Patent
LigandPNGBDBM160520(US9682969, 12 | US10280160, Example 12.)
Affinity DataEC50: <1.00E+4nMAssay Description:Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent