BDBM160129 US10047092, 70::US10053463, 70::US9040534, 70

SMILES Fc1cnc(nc1)-c1nnc2C(=O)N(Cc3cccc(c3Cl)C(F)(F)F)C(Cn12)C1CC1

InChI Key InChIKey=IZKPFCKAFKWGNQ-UHFFFAOYSA-N

Data  4 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 160129   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataIC50: 7.90nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataIC50: 794nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataIC50: 7.90nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataIC50: 794nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataIC50: 7.90nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataIC50: 794nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataKi:  7.90nMAssay Description:Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparation...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataKi:  7.90nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataKi:  7.90nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160129(US10047092, 70 | US9040534, 70 | US10053463, 70)
Affinity DataKi:  7.90nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In DepthDetails
US Patent