BDBM159232 US10195186, Example 47::US9682967, 45

SMILES Cc1cnc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)nc1C

InChI Key InChIKey=SWTSZQOLTCIAHY-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 159232   

TargetSortilin(Human)
H. Lundbeck

US Patent
LigandPNGBDBM159232(US9682967, 45 | US10195186, Example 47)
Affinity DataIC50: 1.20E+3nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSortilin(Human)
H. Lundbeck

US Patent
LigandPNGBDBM159232(US9682967, 45 | US10195186, Example 47)
Affinity DataKi:  190nM IC50: 200nMpH: 7.4Assay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetSortilin(Human)
H. Lundbeck

US Patent
LigandPNGBDBM159232(US9682967, 45 | US10195186, Example 47)
Affinity DataKi:  1.14E+3nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent