BDBM155928 US9018211, 52

SMILES COc1cc(ncc1C#N)[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1

InChI Key InChIKey=QZUKGDYPSXQBSQ-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 155928   

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 36nMpH: 7.4Assay Description:Block of Kir 1.1 (ROMKl) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391 : 85- 100 (1981)) using the IonWork...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 27nMAssay Description:Inhibition of ROMK (unknown origin) expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInward rectifier potassium channel 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Kir2.3 potassium channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInward rectifier potassium channel 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Kir2.1 potassium channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 10(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Kir4.1 potassium channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInward rectifier potassium channel 13(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Kir7.1 potassium channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav1.2 channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 7 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav2.1 channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 14nMAssay Description:Inhibition of rat ROMK by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 32nMAssay Description:Inhibition of ROMK (unknown origin) expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 1.70E+4nMAssay Description:Displacement of [35S]-MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM155928(US9018211, 52)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed