BDBM15492 (3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine::CHEMBL236705::Pyrrolidine-constrained phenethylamine 29a

SMILES N[C@H]1CN(C[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)-c1ccccc1

InChI Key InChIKey=VMMSXEPJIRGODV-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15492   

TargetDipeptidyl peptidase 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM15492((3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-triflu...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM15492((3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-triflu...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human recombinant DPP2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM15492((3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-triflu...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant DPP4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM15492((3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-triflu...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant DPP8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM15492((3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-triflu...)
Affinity DataKi:  20nMAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed