BDBM154671 US8999957, Table 2, Compound 8

SMILES Cn1cc(CN2CCC[C@H](C2)NC(=O)c2ccc3[nH]nc(-c4ccc5OCCc5c4)c3c2)c2ccccc12

InChI Key InChIKey=RGTYBJZXIVQKPF-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 154671   

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154671(US8999957, Table 2, Compound 8)
Affinity DataKd:  11nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154671(US8999957, Table 2, Compound 8)
Affinity DataIC50: 158nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In DepthDetails
US Patent