BDBM154669 US8999957, Table 2, Compound 6

SMILES COc1cccc(F)c1CN1CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1

InChI Key InChIKey=ADVILSOHORXWPG-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 154669   

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154669(US8999957, Table 2, Compound 6)
Affinity DataKd:  0.520nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154669(US8999957, Table 2, Compound 6)
Affinity DataIC50: 33.0nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In DepthDetails
US Patent