BDBM153286 3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-yl)-4,5-dihydro-pyrazole-1-carbothioic acid amide (1a)

SMILES CN(C)c1ccc(C2CC(=NN2C(N)=S)c2cc3ccccc3o2)c2ccccc12

InChI Key InChIKey=YHZCISHSXMKUGS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 153286   

TargetPhospholipase A2 group V(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz

LigandPNGBDBM153286(3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...)
Affinity DataIC50: 3.54E+4nMpH: 7.5 T: 2°CAssay Description:Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz

LigandPNGBDBM153286(3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...)
Affinity DataIC50: 4.53E+3nMpH: 8.0 T: 2°CAssay Description:100 mM Tris HCl buffer, pH 8.0 containing 1 µM heme and COX-1 (ovine) or COX-2(human recombinant), which was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz

LigandPNGBDBM153286(3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...)
Affinity DataIC50: 1.46E+4nMpH: 8.0 T: 2°CAssay Description:100 mM Tris HCl buffer, pH 8.0 containing 1 µM heme and COX-1 (ovine) or COX-2(human recombinant), which was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed