BDBM153159 BDBM153160::US8993756, 4-1

SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(C)=C)c3)c12

InChI Key InChIKey=NJPHKVOXHRAPGJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 153159   

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50: 0.150nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50: 4nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50: 1.48E+3nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK3 (781 to 1124 residues) expressed in baculovirus expression system using FITC-KGGEEEEYFELVK...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK3(Mouse)
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50: 70nMAssay Description:Inhibition of JAK3/JAK1 in mouse CTLL-2 cells assessed as reduction in IL2-stimulated STAT5 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetJAK3/JAK1(Human)
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50: 280nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC CD3+/CD8+ T cells assessed as reduction in IL7-stimulated STAT5 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetJAK3/JAK1(Human)
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of JAK1/JAK3 in human whole blood CD3+/CD4+ T cells assessed as reduction in IL7-stimulated STAT5 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed