BDBM152784 1-[(2,4,6-trimethylphenoxy)propyl]-4-(2-methoxyphenyl)piperazine hydrochloride (4)::CHEMBL4218586

SMILES COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1

InChI Key InChIKey=YGCUSHQLYLUYOC-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 152784   

Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

LigandPNGBDBM152784(CHEMBL4218586 | 1-[(2,4,6-trimethylphenoxy)propyl]...)
Affinity DataKi: <1nM ΔG°: <-12.3kcal/moleT: 2°CAssay Description:The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

LigandPNGBDBM152784(CHEMBL4218586 | 1-[(2,4,6-trimethylphenoxy)propyl]...)
Affinity DataKi: <1nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cell membranes after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

LigandPNGBDBM152784(CHEMBL4218586 | 1-[(2,4,6-trimethylphenoxy)propyl]...)
Affinity DataKi:  157nM ΔG°:  -9.28kcal/moleT: 2°CAssay Description:The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

LigandPNGBDBM152784(CHEMBL4218586 | 1-[(2,4,6-trimethylphenoxy)propyl]...)
Affinity DataKi:  157nMAssay Description:Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM152784(CHEMBL4218586 | 1-[(2,4,6-trimethylphenoxy)propyl]...)
Affinity DataKi:  2.83E+3nMAssay Description:Displacement of [3H]-ketanserin from recombinant human 5-HT2A receptor after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University Medical College

LigandPNGBDBM152784(CHEMBL4218586 | 1-[(2,4,6-trimethylphenoxy)propyl]...)
Affinity DataKi:  8.06E+3nM ΔG°:  -6.94kcal/moleT: 2°CAssay Description:The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed