BDBM152261 US8993552, 4H8 Compound 42

SMILES Nc1cccc(c1)-c1cccnc1

InChI Key InChIKey=YTJQJGKMRLQBJP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 152261   

TargetMenin(Human)
University of Michigan

US Patent
LigandPNGBDBM152261(US8993552, 4H8 Compound 42)
Affinity DataIC50: 5.00E+4nMAssay Description:Assays effective in monitoring the inhibition of the MLL binding to menin were developed during experiments performed during the development of embod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

LigandPNGBDBM152261(US8993552, 4H8 Compound 42)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 (unknown origin) (72 to 385 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM152261(US8993552, 4H8 Compound 42)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of N-terminal GST-tagged MNK1 (unknown origin) (37 to 341 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM152261(US8993552, 4H8 Compound 42)
Affinity DataIC50: 3.63E+5nMAssay Description:Inhibition of Axl (unknown origin) using 5'FAM labeled KKKKEEIYFFF-NH2 peptide as substrate incubated for 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed