BDBM150812 US8981106, 2 (SX-576)::USRE47267, Compound 2

SMILES OB(O)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1

InChI Key InChIKey=AEDMWJARWOMJKQ-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 150812   

TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

US Patent
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50: 22nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2015
Entry Details
Go to US Patent

TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

US Patent
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50: 130nMAssay Description:Inhibition of CXCR2 (unknown origin) expressed in PathHunter celline by beta-arrestin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

US Patent
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50: 21nMAssay Description:Inhibition of CXCR2 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50: 31nMAssay Description:Inhibition of CXCR1 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

US Patent
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

US Patent
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50: 22nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

US Patent
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataEC50:  1.25E+3nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent