BDBM150719 US8981112, 26::US9526727, 26::US9949975, Example 26

SMILES CC[C@@H]1C[C@@]2(Cc3ccc(cc3[C@]22N=C(N)N(CC(C)(C)F)C2=O)C#N)C[C@H](C)[C@H]1OC

InChI Key InChIKey=XXMUGULHTPQVQB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 150719   

TargetBeta-secretase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150719(US8981112, 26 | US9526727, 26 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150719(US8981112, 26 | US9526727, 26 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150719(US8981112, 26 | US9526727, 26 | US9949975, Example...)
Affinity DataIC50: 9nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails
US Patent