BDBM150133 US8975417, 166

SMILES Cc1nnc2c(C)cc(cn12)N1[C@@H](c2c(CO)nn(C3CC3)c2C1=O)c1ccc(Cl)cc1

InChI Key InChIKey=OQBRSKHYDQIBJE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 150133   

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM150133(US8975417, 166)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM150133(US8975417, 166)
Affinity DataIC50: 1.40E+4nMpH: 7.5 T: 2°CAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandPNGBDBM150133(US8975417, 166)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandPNGBDBM150133(US8975417, 166)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM150133(US8975417, 166)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of poly-His tagged CREBBP (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandPNGBDBM150133(US8975417, 166)
Affinity DataIC50: 11nMAssay Description:Inhibition of His-tagged BRD4 (unknown origin) using acetyl-histone H4 as substrate after 35 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed