BDBM148415 US9682963, 8

SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1cccc(SC2CCOC2=O)c1)C(=O)Nc1ccncc1F

InChI Key InChIKey=WGVDEBYCDHJUAL-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148415   

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148415(US9682963, 8)
Affinity DataEC50:  550nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2(Human)
Redx Pharma

US Patent
LigandPNGBDBM148415(US9682963, 8)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO. Required cofactor...More data for this Ligand-Target Pair
In DepthDetails
US Patent