BDBM14713 GGTI-DU40::N-[(1S)-1-carbamoyl-2-phenylethyl]-4-{[1-(3,4-dichlorophenyl)-4-[2-(methylsulfanyl)ethyl]-3-(pyridin-3-yl)-1H-pyrazol-5-yl]oxy}butanamide::N-[(S)-1-carbamoyl-2-phenylethyl]-4-[2-(3,4-di-chlorophenyl)-4-(2-methylsulfanylethyl)-5-pyridin-3-yl-2-H-pyrazol-3-yloxy]butyramide
SMILES CSCCc1c(OCCCC(=O)N[C@@H](Cc2ccccc2)C(N)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1
InChI Key InChIKey=BOIWFQJWKKPATQ-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 14713
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Duke University Medical Center
Duke University Medical Center
Affinity DataIC50: 2.00E+3nMpH: 7.7 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase or GGTase-1 in vitro using purified recombinant mammalian enzymes to catalyze the reactions between [3H]...More data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta [A2V]/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Human)
Duke University Medical Center
Duke University Medical Center
Affinity DataIC50: 8.24nMpH: 7.7 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase or GGTase-1 in vitro using purified recombinant mammalian enzymes to catalyze the reactions between [3H]...More data for this Ligand-Target Pair
TargetGlutathione hydrolase 1 proenzyme(Human)
King Fahd University of Petroleum and Minerals
Curated by ChEMBL
King Fahd University of Petroleum and Minerals
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...More data for this Ligand-Target Pair