BDBM145778 US8952177, 132::US9089569, 132::US9695149, 132

SMILES Cc1cnc(COc2ccc3nc([C@@H]4[C@H](C(O)=O)C4(C)C)n(Cc4ccc(Br)cc4)c3c2)c(F)c1

InChI Key InChIKey=KUZFADIETALJSO-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145778   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM145778(US8952177, 132 | US9695149, 132 | US9089569, 132)
Affinity DataKi:  2.90nMAssay Description:FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM145778(US8952177, 132 | US9695149, 132 | US9089569, 132)
Affinity DataKi:  2.90nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM145778(US8952177, 132 | US9695149, 132 | US9089569, 132)
Affinity DataKi:  2.90nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In DepthDetails
US Patent