BDBM145677 US8952177, 31::US9089569, 31::US9695149, 31

SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1

InChI Key InChIKey=RGPXUDCWUQOZDE-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145677   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM145677(US8952177, 31 | US9695149, 31 | US9089569, 31)
Affinity DataKi:  4.10nMAssay Description:FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM145677(US8952177, 31 | US9695149, 31 | US9089569, 31)
Affinity DataKi:  4.10nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM145677(US8952177, 31 | US9695149, 31 | US9089569, 31)
Affinity DataKi:  4.10nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In DepthDetails
US Patent