BDBM143475 US9682955, 145

SMILES FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1

InChI Key InChIKey=RWFZLPYQONOIGR-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 143475   

TargetCannabinoid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM143475(US9682955, 145)
Affinity DataEC50:  5nMT: 2°CAssay Description:The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetCannabinoid receptor 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM143475(US9682955, 145)
Affinity DataEC50:  801nMT: 2°CAssay Description:The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetCannabinoid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM143475(US9682955, 145)
Affinity DataEC50:  4.60nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as forskolin-stimulated cAMP accumulation after 30 mins by HTRF ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM143475(US9682955, 145)
Affinity DataEC50:  800nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 cells assessed as forskolin-stimulated cAMP accumulation after 30 mins by HTRF ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed