BDBM143359 US9682953, 20.A-3

SMILES Nc1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1

InChI Key InChIKey=UGDNJOZZYFGNIL-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 143359   

TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 361nMpH: 7.4 T: 2°CAssay Description:All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 450nMAssay Description:Inhibition of human transmembrane domain deficient FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 5nMAssay Description:Inhibition of human transmembrane domain deficient FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH cofactor addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH cofactor addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human transmembrane domain deficient FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 31nMAssay Description:Inhibition of rat FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM143359(US9682953, 20.A-3)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed