BDBM142904 US11136327, Example I-21::US8940720, I-21

SMILES COC(=O)Nc1ccc2-c3nc([nH]c3F)[C@H](CCCCC(=O)Nc2c1)NC(=O)c1c(F)cc2n(C)cnc2c1F

InChI Key InChIKey=CECIUFWNAZRBNC-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 142904   

TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM142904(US8940720, I-21 | US11136327, Example I-21)
Affinity DataKi: <5nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
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TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM142904(US8940720, I-21 | US11136327, Example I-21)
Affinity DataKi: <5nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent