BDBM142597 US8933228, Ref 1

SMILES COCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1

InChI Key InChIKey=RTDCVLCTBQDLBW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 142597   

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50: 5nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
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TargetMitogen-activated protein kinase 12(Human)
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US Patent
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50: 402nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
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TargetTyrosine-protein kinase HCK(Human)
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US Patent
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50: 47nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50: 162nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 12(Human)
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US Patent
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant p38 gamma assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
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US Patent
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50: 52nMAssay Description:Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2017
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Respivert

US Patent
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2017
Entry Details Article
PubMed