BDBM141415 US10668051, Compound Example 66::US8921364, 66

SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccncc2)cc1

InChI Key InChIKey=GFXQZHGZXMQDCU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141415   

TargetEF-hand calcium-binding domain-containing protein 4B(Human)
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM141415(US8921364, 66 | US10668051, Compound Example 66)
Affinity DataIC50: 255nMT: 2°CAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
Rhizen Pharmaceuticals

US Patent
LigandPNGBDBM141415(US8921364, 66 | US10668051, Compound Example 66)
Affinity DataIC50: 255nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
In DepthDetails
US Patent