BDBM13986 2-{4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-({4-[3-hydroxy-2-(methoxycarbonyl)phenoxy]butyl}carbamoyl)ethyl]phenoxy}acetic acid::CHEMBL106109::phosphotyrosyl mimetic 17

SMILES COC(=O)c1c(O)cccc1OCCCCNC(=O)[C@H](Cc1ccc(OCC(O)=O)cc1)NC(=O)OC(C)(C)C

InChI Key InChIKey=IKOXRHVKSOJWLA-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 13986   

LigandPNGBDBM13986(CHEMBL106109 | 2-{4-[(2S)-2-{[(tert-butoxy)carbony...)
Affinity DataKi:  2.20E+5nM ΔG°:  -4.94kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Abbott Laboratories

LigandPNGBDBM13986(CHEMBL106109 | 2-{4-[(2S)-2-{[(tert-butoxy)carbony...)
Affinity DataKi: >2.00E+5nM ΔG°: >-4.99kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13986(CHEMBL106109 | 2-{4-[(2S)-2-{[(tert-butoxy)carbony...)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of T-cell Protein Tyrosine Phosphatase (TCPTP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13986(CHEMBL106109 | 2-{4-[(2S)-2-{[(tert-butoxy)carbony...)
Affinity DataKi:  2.20E+5nMAssay Description:Inhibition of Protein-tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13986(CHEMBL106109 | 2-{4-[(2S)-2-{[(tert-butoxy)carbony...)
Affinity DataKi:  2.19E+5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13986(CHEMBL106109 | 2-{4-[(2S)-2-{[(tert-butoxy)carbony...)
Affinity DataKi:  2.20E+5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article