BDBM139539 US8889696, 39

SMILES Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(Sc2ccc(F)cc2)c1=O

InChI Key InChIKey=FJECSOOLAWUZAB-UHFFFAOYSA-N

Data  33 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 139539   

TargetVascular endothelial growth factor receptor 2(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCasein kinase I isoform epsilon(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Lyn(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase Nek1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase Nek1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein kinase C zeta type(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMacrophage-stimulating protein receptor(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAngiopoietin-1 receptor(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ZAP-70(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase PLK2(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 201nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Blk(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ABL1 [1-999,E255K](Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 9.90E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 3(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 9.00E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 8.85E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Lck(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 8.06E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase PLK1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 7.82E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 6.15E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRibosomal protein S6 kinase alpha-1(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 4.25E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase WNK2(Human)
Temple University

US Patent
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: 2.79E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
US Patent