BDBM139469 US8889672, 317-052-004

SMILES COc1cccc(COC(=O)c2c(N)scc2-c2ccc(OC)c(OC)c2)c1

InChI Key InChIKey=KUYKGKWALOSLME-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 139469   

TargetProtein kinase C zeta type(Human)
University of Michigan

US Patent
LigandPNGBDBM139469(US8889672, 317-052-004)
Affinity DataIC50: 5.00E+3nMAssay Description:IC50 values were determined using an in vitro luminescence-based kinase assay against aPKCζ to elucidate a pharmacophore. The IC50 values determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2015
Entry Details
Go to US Patent

TargetProtein kinase C zeta type(Human)
University of Michigan

US Patent
LigandPNGBDBM139469(US8889672, 317-052-004)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of atypical PKCzeta (unknown origin) using CREBtide as substrate incubated for 1 hr measured every 2.5 mins by ADP Quest assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
University of Michigan

US Patent
LigandPNGBDBM139469(US8889672, 317-052-004)
Affinity DataEC50:  1nMAssay Description:Inhibition of atypical PKCzeta in HEK293 cells assessed as TNF-induced NFkappaB activation incubated for 3 hrs prior to TNF induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM139469(US8889672, 317-052-004)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Penn State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM139469(US8889672, 317-052-004)
Affinity DataIC50: 900nMAssay Description:Inhibition of atypical PKCiota (unknown origin) using CREBtide as substrate incubated for 1 hr measured every 2.5 mins by ADP Quest assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed