BDBM138378 US10278929, Compound 27::US11337935, Compound 27::US8877795, 27

SMILES O=C1NC(=O)\C(S1)=C\c1ccccc1OCc1ccccc1

InChI Key InChIKey=CAHCXHIKGCIUCO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 138378   

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM138378(US8877795, 27 | US10278929, Compound 27 | US113379...)
Affinity DataIC50: 5.80E+3nMAssay Description:The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
Go to US Patent

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM138378(US8877795, 27 | US10278929, Compound 27 | US113379...)
Affinity DataIC50: 5.80E+3nMAssay Description:The FP assay was then adapted for HTS and used to screen a 120,000 member small molecule library for compounds that displaced the FP probe from the T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM138378(US8877795, 27 | US10278929, Compound 27 | US113379...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin) using GS-2 peptide substrate incubated for 30 mins by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM138378(US8877795, 27 | US10278929, Compound 27 | US113379...)
Affinity DataIC50: 5.80E+3nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent