BDBM138318 US8877944, 22

SMILES NC(=O)c1cccc2CN(C3CCN(Cc4ccc(Br)cc4)CC3)C(=O)c12

InChI Key InChIKey=UZWHCDLHNJMQBC-UHFFFAOYSA-N

Data  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 138318   

TargetPoly [ADP-ribose] polymerase 1(Mouse)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM138318(US8877944, 22)
Affinity DataKd: <30nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Mouse)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM138318(US8877944, 22)
Affinity DataIC50: 5.99E+3nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138318(US8877944, 22)
Affinity DataKd: <30nMAssay Description:Binding affinity to full length recombinant human PARP-1 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138318(US8877944, 22)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138318(US8877944, 22)
Affinity DataKd:  2.43E+3nMAssay Description:Binding affinity to full length recombinant human PARP-2 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed