BDBM136121 US8853203, 136::US9650377, Example 136

SMILES Fc1cnc(cn1)-c1cccc2C3=CC(=NCC(=O)N3CCc12)n1cnc(n1)C1CC1

InChI Key InChIKey=SRBCTNONXWSPGY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 136121   

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136121(US8853203, 136 | US9650377, Example 136)
Affinity DataIC50: 19nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandPNGBDBM136121(US8853203, 136 | US9650377, Example 136)
Affinity DataIC50: 2.00E+3nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136121(US8853203, 136 | US9650377, Example 136)
Affinity DataIC50: 19nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandPNGBDBM136121(US8853203, 136 | US9650377, Example 136)
Affinity DataIC50: 2.00E+3nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
Go to US Patent