BDBM13319 BMS-386914::CHEMBL183536::[[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]-(1-methyl-1H-imidazole-4-sulfonyl)amino]-acetic Acid tert-Butyl Ester::tert-butyl 2-({6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl}(1-methyl-1H-imidazole-4-)sulfonamido)acetate::tetrahydroquinoline (THQ)-based inhibitor 4a

SMILES Cn1cnc(c1)S(=O)(=O)N(CC(=O)OC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N

InChI Key InChIKey=NLCBWQRVYLSINY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13319   

TargetATP-dependent RNA helicase RhlE(Vibrio fischeri (strain ATCC 700601 / ES114))
University of Washington At Seattle

LigandPNGBDBM13319(tetrahydroquinoline (THQ)-based inhibitor 4a | ter...)
Affinity DataIC50: 0.900nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13319(tetrahydroquinoline (THQ)-based inhibitor 4a | ter...)
Affinity DataIC50: 1.20nMAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13319(tetrahydroquinoline (THQ)-based inhibitor 4a | ter...)
Affinity DataIC50: 30nMAssay Description:Inhibition of cellular reversion in H-ras transformed Rat-1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13319(tetrahydroquinoline (THQ)-based inhibitor 4a | ter...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed