BDBM13217 2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,4,6-trimethylphenyl)-1,3-thiazole-5-carboxamide::BMS-354825 tert-Butoxycarbamate Analog 5a::CHEMBL66109::tert-butyl N-{4-methyl-5-[(2,4,6-trimethylphenyl)carbamoyl]-1,3-thiazol-2-yl}carbamate

SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(C)cc1C

InChI Key InChIKey=CXXAFOANWFBNRW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 13217   

TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

LigandPNGBDBM13217(CHEMBL66109 | 2-[[(tert-Butyloxy)carbonyl]-amino]-...)
Affinity DataIC50: 1.50E+3nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
Bristol-Myers Squibb

LigandPNGBDBM13217(CHEMBL66109 | 2-[[(tert-Butyloxy)carbonyl]-amino]-...)
Affinity DataIC50: 3.00E+3nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

LigandPNGBDBM13217(CHEMBL66109 | 2-[[(tert-Butyloxy)carbonyl]-amino]-...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibition of phosphorylation of an exogenous substrate by human p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

LigandPNGBDBM13217(CHEMBL66109 | 2-[[(tert-Butyloxy)carbonyl]-amino]-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
Bristol-Myers Squibb

LigandPNGBDBM13217(CHEMBL66109 | 2-[[(tert-Butyloxy)carbonyl]-amino]-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed