BDBM13092 CGS 27023A Analog 20::N-hydroxy-2-[(2-methylpropyl)[4-(propan-2-yloxy)benzene]sulfonamido]acetamide::US20230357139, Compound E

SMILES CC(C)CN(CC(=O)NO)S(=O)(=O)c1ccc(OC(C)C)cc1

InChI Key InChIKey=HBUCOYMWRVERSG-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13092   

TargetCollagenase ColH(Hathewaya histolytica)
Artizan Biosciences

US Patent
LigandPNGBDBM13092(N-hydroxy-2-[(2-methylpropyl)[4-(propan-2-yloxy)be...)
Affinity DataIC50: 1.00E+5nMAssay Description:Gelatinase E (Gel E) was purified from bacterial culture supernatant from E. faecalis. E. faecalis was cultured aerobically in Todd Hewitt Broth over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
Go to US Patent

TargetGelatinase(Enterococcus faecalis (strain ATCC 700802 / V583))
Artizan Biosciences

US Patent
LigandPNGBDBM13092(N-hydroxy-2-[(2-methylpropyl)[4-(propan-2-yloxy)be...)
Affinity DataIC50: 1.21E+3nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
Go to US Patent

TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13092(N-hydroxy-2-[(2-methylpropyl)[4-(propan-2-yloxy)be...)
Affinity DataKi:  336nM ΔG°:  -9.18kcal/molepH: 7.5 T: 2°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2007
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM13092(N-hydroxy-2-[(2-methylpropyl)[4-(propan-2-yloxy)be...)
Affinity DataKi:  339nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed