BDBM130903 US10689705, Compound 7::US8829199, 196

SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N

InChI Key InChIKey=OTZMRUFJZIGILY-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 130903   

TargetFibroblast growth factor receptor 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 2.90nMAssay Description:The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 9.40nMAssay Description:The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 130nMAssay Description:The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 280nMAssay Description:Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 390nMAssay Description:Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 130nMAssay Description:Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 3nMAssay Description:Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells assessed as reduction in channel currents at -80 mV holding potential by automated whole-cell patch cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 130nMAssay Description:Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2018
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 2.90nMAssay Description:The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 9.40nMAssay Description:The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM130903(US8829199, 196 | US10689705, Compound 7)
Affinity DataIC50: 130nMAssay Description:The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent