BDBM13080 CGS 27023A Analog 3::N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sulfonamido]acetamide::US20230357139, Compound A::US20240050571, Compound NNGH

SMILES CC(C)C[N@](CC(=O)NO)S(=O)(=O)c1ccc(cc1)OC

InChI Key InChIKey=JIRXORZYIXSWOB-UHFFFAOYSA-N

Data  9 KI  27 IC50

PDB links: 10 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 13080   

TargetCollagenase 3(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 131nMAssay Description:Inhibition of MMP-13 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMeprin A subunit beta(Human)
Fraunhofer Institute For Cell Therapy and Immunology Izi

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH as substrate preincubated for 60 mins followed by substrate addition by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of recombinant human MMP2 using thiopeptide as substrate preincubated for 30 mins followed by substrate addition and measured every mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of recombinant human MMP9 using thiopeptide as substrate preincubated for 30 mins followed by substrate addition and measured every min fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 79nMAssay Description:Inhibition of MMP-9 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 69nMAssay Description:Inhibition of MMP-2 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 31nMAssay Description:Inhibition of MMP-1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 14nMAssay Description:Inhibition of MMP2 using BML-P125-9090 as substrate after 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of MMP2 (unknown origin) using Mca-PLGLDpaAR fluorescent substrate incubated for 2 hrs by microplate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCollagenase ColH(Hathewaya histolytica)
Artizan Biosciences

US Patent
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 612nMAssay Description:Gelatinase E (Gel E) was purified from bacterial culture supernatant from E. faecalis. E. faecalis was cultured aerobically in Todd Hewitt Broth over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
Go to US Patent

TargetGelatinase(Enterococcus faecalis (strain ATCC 700802 / V583))
Artizan Biosciences

US Patent
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 202nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of MMP13 (unknown origin) assessed as reduction in cleavage of colorimetric substrate incubated for 1 hr by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 120nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 2.70nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 5nMAssay Description:Serial dilutions of the compound were prepared with 10% DMSO, and 5 μl of each dilution was added to a 50 μl reaction vessel to result in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 34nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 300nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Protera

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeutrophil collagenase(Human)
Protera

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataKi:  9nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataKi:  132nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataKi:  133nM ΔG°:  -9.75kcal/molepH: 7.5 T: 2°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterstitial collagenase(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataKi:  174nMAssay Description:Inhibition of MMP1 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMeprin A subunit beta(Human)
Fraunhofer Institute For Cell Therapy and Immunology Izi

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of recombinant human meprin beta expressed in baculovirus infected insect cells using N-benzoyl-L-tyrosyl-p-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMeprin A subunit beta(Human)
Fraunhofer Institute For Cell Therapy and Immunology Izi

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of human meprin beta expressed in baculovirus infected BTI-TN-5B1-4 insect cells using N-benzoyl-L-tyrosylp-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed
TargetMatrilysin(Human)
Protera

Curated by ChEMBL
LigandPNGBDBM13080(N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sul...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of MMP7 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed